Monoamine Oxidase AGene polymorphisms and Bipolar Disorder in Iranian Population

monoamine oxidase a gene polymorphisms and bipolar disorder in iranian population

conclusions the obtained results confirm some previous studies regardinga gender specific association of maoa gene with the bipolar disorder. results significant associations were observed regarding maoa-ca (p = 0.016) and maoa-vntr (p = 0.004) polymorphisms in the bipolar females. there was no association between maoa-rflp and bipolar disorder. patients and methods this study is a case-control...

Monoamine Oxidase A Gene Polymorphisms and Bipolar Disorder in Iranian Population

BACKGROUND Bipolar disorder (BPD) is a common and severe mood disorder. Although genetic factors have important rolesin the etiology of bipolar disorder, no specific gene has been identified in relation to this disorder. Monoamine oxidase gene is suggested to be associated with bipolar disorder in many studies. OBJECTIVES This study aimed to investigatethe role of MAOA gene polymorphisms in t...

association of monoamine oxidase b and catechol-o-methyltransferase polymorphisms with sporadic parkinson’s disease in an iranian population

Association of monoamine oxidase B and catechol-O-methyltransferase polymorphisms with sporadic Parkinson's disease in an Iranian population.

Genetic polymorphisms have been shown to be involved in dopaminergic neurotransmission. This may influence susceptibility to Parkinson's disease (PD). We performed a case-control study of the association between PD susceptibility and a genetic polymorphism of MAOB and COMT, both separately and in combination, in Iranians. The study enrolled 103 Iranian patients with PD and 70 healthy individual...

A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder.

The genes encoding for the enzymes monoamine oxidase (MAO) A and B are good candidates to investigate bipolar affective disorder. A 30 bp repeat in the MAOA promoter was recently demonstrated to be polymorphic and to affect transcriptional activity. In a family-based association design we found that none of the different repeat copies was preferentially transmitted from mothers (n = 131) to the...